Read the following paragraph and choose the best topic sentence from the four options that follow. Write the corresponding letter of your choice on the answer sheet.

Art can be almost anything. It has changed almost every day since the first artist created the first work at least fifty thousand years ago. The most significant changes have been brought about by the genius of a single artist. Some changes have come about through the invention of new media and new techniques—say, the birth of manuscript illumination, oil paint, or perspective. Other changes have come about because a young artist threw aside all traditions and depicted his or her world in a fresh, different, and completely new way. Each change was initially looked upon with suspicion as to its artistic worth, but in time, each was accepted. And the same will be true of all the weird subjects, styles, and media that will show up in the future.